Hepatocyte Nuclear Factor 4 Is a Transcription Factor that Constitutively Binds Fatty Acids
نویسندگان
چکیده
منابع مشابه
Nuclear factor-kappaB p65 (RelA) transcription factor is constitutively activated in human colorectal carcinoma tissue.
AIM Activation of transcription factor nuclear factor-kappaB (NF-kappaB) has been shown to play a role in cell proliferation, apoptosis, cytokine production, and oncogenesis. The purpose of this study was to determine whether NF-kappaB was constitutively activated in human colorectal tumor tissues and, if so, to determine the role of NF-kappaB in colorectal tumorigenesis, and furthermore, to de...
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HNF-4 (hepatocyte nuclear factor 4) is a key regulator of liverspecific gene expression in mammals. We have shown previously that the activity of the human APOC3 (apolipoprotein C-III) promoter is positively regulated by the anti-inflammatory cytokine TGFβ (transforming growth factor β) and its effectors Smad3 (similar to mothers against decapentaplegic 3) and Smad4 proteins via physical and fu...
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ژورنال
عنوان ژورنال: Structure
سال: 2002
ISSN: 0969-2126
DOI: 10.1016/s0969-2126(02)00829-8